刘成栋 博士 副教授
E-mail：[email protected]
教育背景：
2009年于山东师范大学获学士学位，2012年于中国海洋大学获硕士学位，2016年于中国海洋大学获博士学位，2016-2018年在美国密歇根大学进行博士后研究。 2019年起受聘中国海洋大学“青年英才工程”第三层次岗位至今
主要研究方向及成果：1）利用斑马鱼模型研究水生动物盐度和缺氧等环境应激的分子调控机制；2）解析IGF-TOR信号通路对细胞增殖分化的调控机制；3）营养感知与环境应激的交互影响，结合分子营养学理论，提高水产动物的抗逆能力。
主要主持和参与科研项目：
1. 国家重点研发计划子课题
2. 国家自然科学基金青年基金
3. 山东省自然科学基金青年基金
4. 中国博士后科学基金面上项目（一等）
主要发表文章：
1. Liu, C., Li, S., Noer, P.R., Kjaer-Sorensen, K., Juhl, A.K., Goldstein, A., Ke, C., Oxvig, C. and Duan, C.*, 2020. The metalloproteinase Papp-aa controls epithelial cell quiescence-proliferation transition. Elife, 9, p.e52322.
2. Liu, C., Xin, Y., Bai, Y., Lewin, G., He, G., Mai, K. and Duan, C.*, 2018. Ca 2+ concentration-dependent premature death of igfbp5a-/-fish reveals a critical role of IGF signaling in adaptive epithelial growth. Science Signaling, 11(548).
3. Tang M, Xia W, Song F, Liu C, Wang X, Zhou H, Mai K and He G. Loss of Gcn2 exacerbates gossypol induced oxidative stress, apoptosis and inflammation in zebrafish. Fish & Shellfish Immunology, 151 (2024), 109727.
4. Li Y, Liu C, Rolling L, Sikora V, Chen Z, Gurwin J, Barabell C, Lin J and Duan C. ROS signaling–induced mitochondrial Sgk1 expression regulates epithelial cell renewal. Proceedings of the National Academy of Sciences, 120 (24) (2023), e2216310120.
5. Wu, X., Chen, J., Liu, C.*, Wang, X., Zhou, H., Mai, K. and He, G., 2022. Slc38a9 Deficiency Induces Apoptosis and Metabolic Dysregulation and Leads to Premature Death in Zebrafish. International journal of molecular sciences, 23(8), p.4200.
6. Wei, C., Liu, C.*, Wang, X., Zhou, H., Mai, K. and He, G., 2021. Dietary arachidonic acid supplementation improves the growth performance and alleviates plant protein‐based diet‐induced inflammation in juvenile turbot (Scophthalmus maximus L.). Aquaculture Nutrition, 27(2), pp.533-543.
7. Liu, C., Wang, X., Zhou, H., Mai, K. and He, G.*, 2019. Recent advances in amino acid sensing and new challenges for protein nutrition in aquaculture. Marine Life Science & Technology, 1(1), pp.50-59.
8. Liu, C., Dai, W., Bai, Y., Chi, C., Xin, Y., He, G., Mai, K. and Duan, C.*, 2017. Development of a whole organism platform for phenotype-based analysis of IGF1R-PI3K-Akt-Tor action. Scientific reports, 7(1), pp.1-15.